MicroRNAs Responsible for Inflammation in Obesity

Autor(en)

Caroline Brettfeld, Ales Maver , Borut Peterlin, Alexander Haslberger

Abstrakt

Background: In recent years, more and more evidence has accumulated to elucidate the modulating roles of microRNA in immune and inflammatory system. We conducted a novel positional omics integration study to identify microRNAs that could shed further light on the possible links between microRNAs, adipose tissue immunity/inflammation and obesity.

Methods: In contrast to previous methodologies employed for integration of heterogeneous OMIC data, we based the integration on genomic positions of alterations in human disease and employed an additional weighing step. A data search for various types of studies on obesity (genome-wide association, meta-analysis, transcriptomic, proteomic studies and epigenetic studies) was conducted to establish the initial data set.

Results and discussion: The analysis identified 19 high scoring microRNAs (miR-146, miR-378, miR-143, miR-145, miR-194, miR-1273, miR-190, miR-561, miR-151, miR-215, miR-196, miR-328, miR-208, miR-3155A, miR-933, miR-4685, miR-640, miR-4659, and miR-877). Five (miR-146, miR-378, miR-143, miR-145, and miR-194), which may be directly linked to adipose tissue inflammation or obesity-related diseases, eight other microRNAs (miR-1273, miR-190, miR-561, miR-151, miR-215, miR-196, miR-328, and miR-208) have been identified to play a role in cancer and myocardial infarction, where obesity is a defined risk factor.

Conclusion: In this study, we applied a new method of positional integrational analysis of different OMIC-layers and utilized an additional validation step through weighing. Our study yields a number of plausible microRNAs that provide an interesting basis for further research to elucidate underlying mechanisms of obesity. Our detection of common microRNAs which are also related with an increased risk for inflammations, cardiovascular problems and type 2 diabetes, irrespectively of gender and age may provide a path for understanding the inherited or acquired impact of microRNAs on human health and wellbeing.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

University of Ljubljana

Journal

Journal of Endocrinology and metabolisms

Band

7

Seiten

77-85

Anzahl der Seiten

9

ISSN

1923-2861

DOI

https://doi.org/10.14740/jem399w

Publikationsdatum

2017

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/d275443c-d64c-433a-829b-6f03dd5a7e5c