Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity – implications for improved metabolic health
- Autor(en)
- Nazlisadat Seyed Khoei, Annemarie Grindel, Marlies Wallner, Christine Mölzer, Daniel Doberer, Rodrig Marculescu, Andrew Bulmer, Karl-Heinz Wagner
- Abstrakt
Background and aims: Mild endogenous elevation of unconjugated bilirubin (UCB) as seen in Gilbert's syndrome (GS), might mitigate cardiovascular disease (CVD) risk factors including overweight/obesity. This study aimed to determine whether hyperbilirubinaemia is linked to improved anthropometric data and lipid profile. Methods: Our study considered GS and age-/gender-matched healthy controls (n = 248). Additionally, obese female type 2 diabetic patients (DM2) (n = 26) were included as a “disease control group”. Results: BMI, hip circumference (HC), and lipid profile were significantly lower in GS. UCB was inversely correlated with BMI (p <0.001), HC as well as with fat mass (FM) and lipid variables (p < 0.05). Moreover, DM2 patients had significantly lower UCB compared to GS and healthy controls. Older GS subjects (≥35 years) had significantly reduced anthropometric data and improved lipid profile. Conclusions: Our results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia.
- Organisation(en)
- Department für Ernährungswissenschaften, Forschungsplattform Active Ageing
- Externe Organisation(en)
- Medizinische Universität Wien, Fachhochschule Joanneum, University of Aberdeen, Griffith University
- Journal
- Atherosclerosis
- Band
- 269
- Seiten
- 306–311
- Anzahl der Seiten
- 6
- ISSN
- 0021-9150
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2017.12.021
- Publikationsdatum
- 12-2017
- Peer-reviewed
- Ja
- ÖFOS 2012
- 303026 Public Health
- Schlagwörter
- ASJC Scopus Sachgebiete
- Cardiology and Cardiovascular Medicine
- Sustainable Development Goals
- SDG 3 – Gesundheit und Wohlergehen
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/9274a5ef-a64c-4239-a0ff-0e1496cb7f66