Four-year study of cobalt and chromium blood levels in patients managed with two different metal-on-metal total hip replacements

Autor(en)

Christian G. Lhotka, Thomas Szekeres, Ilse Steffan, Klaus Zhuber, Karl A. Zweymüller

Abstrakt

Background: Metal-on-metal total hip prostheses will produce a certain amount of wear debris. This results in increased whole-blood metal levels, which may cause adverse effects. It is not known to what extent the problem has been overcome by advances in alloy technology. Methods: In 259 patients who with total hip replacement, blood cobalt and chromium concentrations were measured with atomic absorption spectrophotometry over a period of four years after arthroplasty. Of the patients enrolled in the study, 131 had been managed with a METASUL� cobalt-chromium alloy metal-on-metal bearing combination, while 128 had been given a SIKOMET�-SM21� cobalt-chromium alloy metal-on-metal combination. The control group consisted of 31 age- and gender-matched subjects. Results: Compared with the controls, all the patients had higher cobalt and chromium levels. Cobalt concentrations were up to 50 times higher, while chromium concentrations were up to 100 times higher. Conclusions: Both systems showed evidence, in the whole-blood samples, of wear debris production by the implants. Therefore, patients managed with metal-on-metal bearing combinations should be carefully monitored in order to ensure that any local or systemic complications are detected early on. Œ 2003 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.

Organisation(en)

Institut für Analytische Chemie

Externe Organisation(en)

Orthopädisches Krankenhaus Gersthof, a.ö. Krankenhaus der Barmherzigen Schwestern vom Heiligen Kreuz Wels, Medizinische Universität Wien

Journal

Journal of Orthopaedic Research: a journal for musculoskeletal investigations

Band

21

Seiten

189-195

Anzahl der Seiten

7

ISSN

0736-0266

DOI

https://doi.org/10.1016/S0736-0266(02)00152-3

Publikationsdatum

2003

Peer-reviewed

Ja

ÖFOS 2012

1040 Chemie

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/fouryear-study-of-cobalt-and-chromium-blood-levels-in-patients-managed-with-two-different-metalonmetal-total-hip-replacements(2e9e03ec-f711-46ba-8edd-cc6e05598c98).html