Four-year study of cobalt and chromium blood levels in patients managed with two different metal-on-metal total hip replacements
- Autor(en)
- Christian G. Lhotka, Thomas Szekeres, Ilse Steffan, Klaus Zhuber, Karl A. Zweymüller
- Abstrakt
Background: Metal-on-metal total hip prostheses will produce a certain amount of wear debris. This results in increased whole-blood metal levels, which may cause adverse effects. It is not known to what extent the problem has been overcome by advances in alloy technology. Methods: In 259 patients who with total hip replacement, blood cobalt and chromium concentrations were measured with atomic absorption spectrophotometry over a period of four years after arthroplasty. Of the patients enrolled in the study, 131 had been managed with a METASUL� cobalt-chromium alloy metal-on-metal bearing combination, while 128 had been given a SIKOMET�-SM21� cobalt-chromium alloy metal-on-metal combination. The control group consisted of 31 age- and gender-matched subjects. Results: Compared with the controls, all the patients had higher cobalt and chromium levels. Cobalt concentrations were up to 50 times higher, while chromium concentrations were up to 100 times higher. Conclusions: Both systems showed evidence, in the whole-blood samples, of wear debris production by the implants. Therefore, patients managed with metal-on-metal bearing combinations should be carefully monitored in order to ensure that any local or systemic complications are detected early on. Œ 2003 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
- Organisation(en)
- Institut für Analytische Chemie
- Externe Organisation(en)
- Orthopädisches Krankenhaus Gersthof, a.ö. Krankenhaus der Barmherzigen Schwestern vom Heiligen Kreuz Wels, Medizinische Universität Wien
- Journal
- Journal of Orthopaedic Research: a journal for musculoskeletal investigations
- Band
- 21
- Seiten
- 189-195
- Anzahl der Seiten
- 7
- ISSN
- 0736-0266
- DOI
- https://doi.org/10.1016/S0736-0266(02)00152-3
- Publikationsdatum
- 2003
- Peer-reviewed
- Ja
- ÖFOS 2012
- 1040 Chemie
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/2e9e03ec-f711-46ba-8edd-cc6e05598c98