Data on the highly diverse plasma response to a drink containing nutrients

Autor(en)
Sandra Unterberger, Alexandra Maier-Salamon, Walter Jäger, Barbara Wessner, Karl-Heinz Wagner
Abstrakt

Bioavailability of nutrients is highly diverse and depends on a variety of endogenous and exogenous factors in humans. This data article reports on the plasma response of 10 human subjects (5 females, 5 males) to a single dose of a multivitamin drink within 6h (blood taken after 1, 2, 4, and 6h). Nutrients, which were considered in the assessment, were folate (Radioimmuno Assay), vitamin B12 (Radioimmuno Assay) and resveratrol and its plasma metabolites resveratrol-3-O-glucuronide (R3G), resveratrol-4'-O-glucuronide (R4G), resveratrol-3-O-sulfate (R3S) and resveratrol-3-O-4'-O-disulfate (RD, all HPLC). Biological outcome measures were malondialdehyde (MDA, HPLC) and Ferric Reducing ability potential (FRAP, Microplate reader). Mean plasma concentration increased over time significantly for folate (p < 0.05, maximum concentration (Tmax) after 2h), R3G, R4G, R3S (all p < 0.05, Tmax after 1h), RD (p < 0.05, Tmax after 2h) as well as MDA, which decreased (p < 0.05, Tmax after 2h). No significant change was observed for vitamin B12 and FRAP. Within this mean development, individual changes of participants were highly diverse such as for folate from +42 to +422%, for MDA from -49 to +30% or vitamin B12 from -4 to +33%. For R4G 4 out of 10 subjects showed even no increase in plasma at all. For R4G plasma response ranged from 0 to 36 ng/ml, for R3G from 0 to 53 ng/ml or for R4S from 62 to 265 ng/ml. There was no gender difference regarding the plasma response.

Organisation(en)
Forschungsplattform Active Ageing, Department für Pharmazeutische Chemie, Institut für Sportwissenschaft, Department für Ernährungswissenschaften
Journal
Data in Brief
Band
29
Seiten
105309
ISSN
2352-3409
DOI
https://doi.org/10.1016/j.dib.2020.105309
Publikationsdatum
04-2020
Peer-reviewed
Ja
ÖFOS 2012
303009 Ernährungswissenschaften, 303028 Sportwissenschaft
Link zum Portal
https://ucris.univie.ac.at/portal/de/publications/data-on-the-highly-diverse-plasma-response-to-a-drink-containing-nutrients(eb31301f-3571-4288-a2c7-a3cf5033344c).html