Monoacyl-Phospatidylcholine Nanostructured Lipid Carriers: Influence of Lipid and Surfactant Content on in Vitro Skin Permeation of Flufenamic Acid and Fluconazole

Autor(en)
Martin Wolf, Victoria Klang, Maria Halper, Constanze Stix, T. Heuser, Harald Kotisch, Claudia Valenta
Abstrakt

Monoacyl-phosphatidylcholine (MAPL) is a skin-friendly phospholipid emulsifier that has successfully been employed for development of microemulsions. Its potential for stabilising particulate lipid drug carriers has not been explored so far. Thus, the aim of the present study was the development of MAPL-based nanostructured lipid carriers (NLC) as dermal drug delivery system with optimised physical stability. To this end, extensive comparative studies were performed and the role of crucial formulation parameters such as total lipid or surfactant content was investigated. Both blank placebo NLC and drug-loaded systems were developed using flufenamic acid and fluconazole as model drugs of different polarity. The resulting systems were characterised using photon correlation spectroscopy, laser Doppler electrophoresis, rheological measurements and cryo transmission electron microscopy. In vitro skin diffusion studies revealed that interestingly, both a low surfactant content and a low total lipid content led to increased skin permeation of flufenamic acid in vitro. According to its different polarity, a different trend was observed for fluconazole where higher surfactant contents in combination with different total lipid contents yielded the highest skin permeation. Satisfying long-term stability of the NLC formulations with optimised physical parameters was observed for a period of 30 weeks.

Organisation(en)
Organisationskultur und Gleichstellung
Externe Organisation(en)
Vienna BioCenter
Journal
Journal of Drug Delivery Science and Technology
Band
41
Seiten
419-430
Anzahl der Seiten
12
ISSN
1773-2247
DOI
https://doi.org/10.1016/j.jddst.2017.08.016
Publikationsdatum
10-2017
Peer-reviewed
Ja
ÖFOS 2012
301209 Pharmazie, 103042 Elektronenmikroskopie, 301208 Pharmazeutische Technologie
Schlagwörter
ASJC Scopus Sachgebiete
Pharmaceutical Science
Link zum Portal
https://ucris.univie.ac.at/portal/de/publications/monoacylphospatidylcholine-nanostructured-lipid-carriers-influence-of-lipid-and-surfactant-content-on-in-vitro-skin-permeation-of-flufenamic-acid-and-fluconazole(f625d7c4-ce74-49f3-87fa-86f354328c9d).html